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| Nomenclature |
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Symbol:
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Rxratm1Ipc
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Name:
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retinoid X receptor alpha;
targeted mutation 1, Pierre Chambon
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MGI ID: |
MGI:1857511 |
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Synonyms: |
Rxr alpha AF2I, Rxralphaaf2(l), Rxr alpha AF2O |
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Gene:
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Rxra
Location:
Chr2:27676440-27762957 bp, + strand
Genetic Position: Chr2,
19.38 cM
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Rxratm1Ipc/Rxratm4Ipc Rxrbtm1Mma/Rxrbtm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice develop alopecia but no skin inflammation while Rxratm4Ipc/Rxratm4Ipc Rxrbtm1Pcn/Rxrbtm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice show both hair loss and skin inflammation
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:50515
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Parent Cell Line:
| H1 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Nucleotide substitutions |
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Mutation details: This allele encodes a protein that lacks the final 18 amino acids (position 450 to 467) due to a nonsense mutation introduced into exon 10. The deletion corresponds to the last alpha helical structure (helix 12) of the ligand binding domain. A floxed neo cassette was inserted into intron 9 for selection.
(J:50515)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Rxra Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:50515
Mascrez B et al.,
"The RXRalpha ligand-dependent activation function 2 (AF-2) is important for mouse development."
Development 1998 Dec;125(23):4691-707
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All: |
14 reference(s)
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Analysis Tools
