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| Nomenclature |
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Symbol:
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Ednratm1Ywa
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Name:
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endothelin receptor type A;
targeted mutation 1, Masashi Yanagisawa
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MGI ID: |
MGI:1857473 |
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Synonyms: |
ET/A - |
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Gene:
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Ednra
Location:
Chr8:77663031-77724464 bp, - strand
Genetic Position: Chr8,
36.63 cM, cytoband C2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:46639
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Parent Cell Line:
| JH1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 5 and 6, which encode the sixth and seventh transmembrane domains of the protein. Radioligand binding assays on samples derived from skin of homozygous embryos demonstrated that no functional protein was produced from this allele. (J:46639)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:46639
Clouthier DE et al.,
"Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice."
Development 1998 Mar;125(5):813-24
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All: |
11 reference(s)
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Analysis Tools
