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| Nomenclature |
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Symbol:
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Gcktm1Ts
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Name:
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glucokinase;
targeted mutation 1, Timothy Stewart
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MGI ID: |
MGI:1857469 |
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Synonyms: |
GKKO, GLK- |
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Gene:
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Gck
Location:
Chr11:5900820-5950081 bp, - strand
Genetic Position: Chr11,
3.88 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:29255
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Parent Cell Line:
| AB1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprt+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced all of exon 4 and parts of exons 3 and 5 of the gene. Northern blots of liver from heterozygous and homozygous mutant mice showed decreased levels of mRNA and no detectable mRNA, respectively, for the gene of interest. Enzymatic activity in both pancreatic islet cells and liver from heterozygous mutant mice was approximately 60% of wild-type littermates. Enzymatic activity in liver from homozygous mutant mice was undetectable. (J:29255)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:29255
Grupe A et al.,
"Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis."
Cell 1995 Oct 6;83(1):69-78
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All: |
2 reference(s)
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Analysis Tools
