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| Nomenclature |
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Symbol:
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Ciitatm1Ccum
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Name:
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class II transactivator;
targeted mutation 1, Cheong-Hee Chang
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MGI ID: |
MGI:1857456 |
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Synonyms: |
CIITA-, CIITA C-, MHC classII- |
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Gene:
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Ciita
Location:
Chr16:10488178-10527564 bp, + strand
Genetic Position: Chr16,
5.65 cM, cytoband B1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:31601
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A genomic fragment containing exons which encode critical regions of the protein was replaced with a neomycin selection gene. Northern blot analysis on RNA derived from homozygous mice demonstrated that no detectable protein was produced from this allele. (J:31601)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:31601
Chang CH et al.,
"Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression."
Immunity 1996 Feb;4(2):167-78
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All: |
45 reference(s)
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Analysis Tools
