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| Nomenclature |
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Symbol:
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Rbl2tm1Tyj
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Name:
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retinoblastoma-like 2;
targeted mutation 1, Tyler Jacks
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MGI ID: |
MGI:1857449 |
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Synonyms: |
p130- |
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Gene:
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Rbl2
Location:
Chr8:91070057-91123844 bp, + strand
Genetic Position: Chr8,
44.25 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:34725
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced sequences in a proximal exon of the Rbl2 gene. Rbl2 mRNA levels in liver cells of homozygous mutant animals were reduced more than five fold compared to wild-type. Immunoblot analysis did not detect RBL2 protein in embryonic fibroblasts or in adult liver of homozygous mutant mice. (J:34725)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:34725
Cobrinik D et al.,
"Shared role of the pRB-related p130 and p107 proteins in limb development."
Genes Dev 1996 Jul 1;10(13):1633-44
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All: |
27 reference(s)
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Analysis Tools
