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| Nomenclature |
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Symbol:
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Rbl1tm1Tyj
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Name:
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retinoblastoma-like 1 (p107);
targeted mutation 1, Tyler Jacks
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MGI ID: |
MGI:1857448 |
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Synonyms: |
p107- |
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Gene:
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Rbl1
Location:
Chr2:157145893-157204534 bp, - strand
Genetic Position: Chr2,
78.05 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:34058
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A PGK-neomycin cassette replaced sequences in exon 1 and a downstream intron of the Rbl1 gene. The authors predict that the mutant allele will synthesize only the first 22 amino acids of the wild-type protein. RBL1 protein was not detected in embryonic fibroblasts derived from homozygous mutant mice, or in homozygous mutant E18 embryos. Rbl1 transcript was not detected in homozygous mutant E18 embryos. (J:34058)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:34058
Lee MH et al.,
"Targeted disruption of p107: functional overlap between p107 and Rb."
Genes Dev 1996 Jul 1;10(13):1621-32
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All: |
40 reference(s)
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Analysis Tools
