Ptch1tm1Mps
Targeted Allele Detail
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| Nomenclature |
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Symbol:
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Ptch1tm1Mps
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Name:
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patched homolog 1;
targeted mutation 1, Matthew P Scott
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MGI ID: |
MGI:1857447 |
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Synonyms: |
LacZ/Ptc, ptc-, Ptc1-, Ptc1-lacZ, Ptc1lzki, Ptch-, Ptch1-, Ptch1-lacZ, PtchKO1, PtchlacZ, ptc-lacZ, PtclacZ, Ptcn |
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Gene:
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Ptch1
Location:
Chr13:63511533-63565520 bp, - strand
Genetic Position: Chr13,
32.8 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:42441
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A construct containing a promoterless lacZ-neo fusion gene was inserted at the start codon and deleted a portion of exon 1 and all of exon 2, which encoded the first transmembrane domain. Expression of the inserted lacZ gene served as an accurate reporter in heterozygotes but was found to be derepressed in homozygous mutant mice. (J:42441)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:42441
Goodrich LV et al.,
"Altered neural cell fates and medulloblastoma in mouse patched mutants."
Science 1997 Aug 22;277(5329):1109-13
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All: |
178 reference(s)
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Analysis Tools
