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| Nomenclature |
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Symbol:
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Plp1tm1Kan
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Name:
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proteolipid protein (myelin) 1;
targeted mutation 1, Klaus-Armin Nave
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MGI ID: |
MGI:1857446 |
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Synonyms: |
Plp-, PLP/DM20 null, PLP-null |
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Gene:
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Plp1
Location:
ChrX:136822671-136839733 bp, + strand
Genetic Position: ChrX,
59.1 cM, cytoband F1-F2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:38856
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette introduced by homologous recombination replaced the 3' part of exon 1,including the translation start codon and a 2.5 kb fragment of the first intron of Plp ("PLP/DM20 gene"). Western blot analysis showed absence of both PLP and DM20 proteolipids proteins in hemizygous mutant mice. (J:38856)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:38856
Klugmann M et al.,
"Assembly of CNS myelin in the absence of proteolipid protein."
Neuron 1997 Jan;18(1):59-70
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All: |
17 reference(s)
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Analysis Tools
