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| Nomenclature |
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Symbol:
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L1camtm1Sor
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Name:
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L1 cell adhesion molecule;
targeted mutation 1, Philippe Soriano
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MGI ID: |
MGI:1857443 |
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Synonyms: |
L1- |
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Gene:
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L1cam
Location:
ChrX:73853778-73896105 bp, - strand
Genetic Position: ChrX,
37.43 cM, cytoband A6-B
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Cerebellar abnormalities in L1camtm1Sor/Y Nrcamtm1Gmt/Nrcamtm1Gmt mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:45013
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Parent Cell Line:
| AB1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprt+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced the exons encoding the sixth immunoglobulin-like domain of the protein. Immunoblots of lysates of adult brains from homozygous mutant mice showed an absence of normal protein. (J:45013)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:45013
Cohen NR et al.,
"Errors in corticospinal axon guidance in mice lacking the neural cell adhesion molecule L1."
Curr Biol 1998 Jan 1;8(1):26-33
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All: |
14 reference(s)
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Analysis Tools
