|
|
| Nomenclature |
|
Symbol:
|
Htr2ctm1Jul
|
|
Name:
|
5-hydroxytryptamine (serotonin) receptor 2C;
targeted mutation 1, David Julius
|
|
MGI ID: |
MGI:1857439 |
|
Synonyms: |
5-HT2cR-deficient |
|
Gene:
|
Htr2c
Location:
ChrX:146962513-147197277 bp, + strand
Genetic Position: ChrX,
68.46 cM, cytoband D-F4
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:24339
|
|
Parent Cell Line:
| Other (see notes) (ES Cell) |
|
Strain of Origin:
|
129S/Sv
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Nucleotide substitutions |
| |
|
Mutation details: Insertion of a nonsense mutation into exon 5 of the gene resulted in the introduction of a stop codon within the fifth putative transmembrane segment of the receptor and in the elimination of the carboxy-terminal half of the protein. (J:24339)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
|
Notes |
ES cell line = D3 (129S2/SvPas) or J1 (129S4/SvJae).
|
| References |
|
Original: |
J:24339
Tecott LH et al.,
"Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors [see comments]"
Nature 1995 Apr 6;374(6522):542-6
|
|
All: |
31 reference(s)
|
|
Analysis Tools
