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| Nomenclature |
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Symbol:
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Gria2tm1Rod
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Name:
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glutamate receptor, ionotropic, AMPA2 (alpha 2);
targeted mutation 1, John Roder
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MGI ID: |
MGI:1857436 |
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Synonyms: |
GluA2, GluR2- |
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Gene:
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Gria2
Location:
Chr3:80684936-80802791 bp, - strand
Genetic Position: Chr3,
35.5 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:64275
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced exon 11 of the gene, which encodes the pore loop and transmembrane region, TM1. Western blots of brain plasma membranes from homozygous mutant mice showed no detectable protein for the targeted gene. (J:64275)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:64275
Jia Z et al.,
"Enhanced LTP in mice deficient in the AMPA receptor GluR2."
Neuron 1996 Nov;17(5):945-56
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All: |
21 reference(s)
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Analysis Tools
