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| Nomenclature |
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Symbol:
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Col4a3tm1Dec
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Name:
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collagen, type IV, alpha 3;
targeted mutation 1, Dominic Cosgrove
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MGI ID: |
MGI:1857432 |
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Gene:
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Col4a3
Location:
Chr1:82586921-82722059 bp, + strand
Genetic Position: Chr1,
42.32 cM
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Sostdc1tm1Myan/Sostdc1tm1Myan Col4a3tm1Dec/Col4a3tm1Dec mice show less glomerular and tubular injury than Col4a3tm1Dec/Col4a3tm1Dec mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:37963
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin selection cassette was inserted into exon 5. Northern blot analysis on RNA derived from kidney of homozygous mice demonstrated that no detectable transcript is produced from this allele. Immunohistochemistry experiments on kidney sections from homozygous mice confirmed that no detectable protein is made. (J:37963)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:37963
Cosgrove D et al.,
"Collagen COL4A3 knockout: a mouse model for autosomal Alport syndrome."
Genes Dev 1996 Dec 1;10(23):2981-92
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All: |
31 reference(s)
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Analysis Tools
