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| Nomenclature |
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Symbol:
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Col3a1tm1Jae
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Name:
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collagen, type III, alpha 1;
targeted mutation 1, Rudolf Jaenisch
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MGI ID: |
MGI:1857431 |
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Gene:
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Col3a1
Location:
Chr1:45311538-45349706 bp, + strand
Genetic Position: Chr1,
23.67 cM
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Col3a1tm1Jae/Col3a1tm1Jae mouse with skin lesion
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:39273
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette replaced a genomic fragment containing the promoter region and first exon of the gene. Protein analysis of isolated tail and skin collagens from homozygous mice demonstrated that no stable protein was produced from this allele. (J:39273)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:39273
Liu X et al.,
"Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development."
Proc Natl Acad Sci U S A 1997 Mar 4;94(5):1852-6 SS 18 /C?
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All: |
3 reference(s)
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Analysis Tools
