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| Nomenclature |
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Symbol:
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Ahrtm1Bra
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Name:
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aryl-hydrocarbon receptor;
targeted mutation 1, Christopher A Bradfield
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MGI ID: |
MGI:1857427 |
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Synonyms: |
Ahr-, AhrKO |
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Gene:
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Ahr
Location:
Chr12:35497974-35535038 bp, - strand
Genetic Position: Chr12,
15.78 cM
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Liver abnormalities in Ahrtm1Bra/Ahrtm1Bra mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:33827
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin selection cassette replaced a genomic fragment containing exon 2, which encodes the basic-HLH domain essential for dimerization and DNA binding. Western blot analysis on liver cytosol demonstrated that the protein was not detectable in homozygous mice. (J:33827)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:33827
Schmidt JV et al.,
"Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development."
Proc Natl Acad Sci U S A 1996 Jun 25;93(13):6731-6
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All: |
55 reference(s)
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Analysis Tools
