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| Nomenclature |
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Symbol:
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E2f1tm1Meg
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Name:
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E2F transcription factor 1;
targeted mutation 1, Michael E Greenburg
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MGI ID: |
MGI:1857424 |
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Synonyms: |
E2f1-, E2F-1- |
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Gene:
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E2f1
Location:
Chr2:154559407-154569892 bp, - strand
Genetic Position: Chr2,
76.79 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:33100
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Part of exon 3, intron 3 and exon 4 were replaced with a neomycin cassette. These sequences encode residues encoding the leucine zipper and those critical for DNA binding. Northern blot analysis did not detect a transcript made from this allele in fibroblasts isolated from homozygous embryos. (J:33100)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:33100
Field SJ et al.,
"E2F-1 functions in mice to promote apoptosis and suppress proliferation."
Cell 1996 May 17;85(4):549-61
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All: |
63 reference(s)
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Analysis Tools
