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| Nomenclature |
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Symbol:
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Crhtm1Maj
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Name:
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corticotropin releasing hormone;
targeted mutation 1, Joseph Majzoub
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MGI ID: |
MGI:1857392 |
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Synonyms: |
CRH -, CRHKO, CRH KO, CRH-KO |
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Gene:
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Crh
Location:
Chr3:19693401-19695396 bp, - strand
Genetic Position: Chr3,
5.75 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:23082
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The sequences encoding the pre-propeptide region were replaced by a neomycin resistance cassette. RT-PCR analysis demonstrated that the transcript was absent in whole brain RNA derived from homozygous mice. Immunohistochemical analysis demonstrated that the protein was not detectable in sections of the amygdala and cerebral cortex of brains of homozygous mice. (J:17994, J:23082, J:47705)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:23082
Muglia L et al.,
"Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need."
Nature 1995 Feb 2;373(6513):427-32
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All: |
40 reference(s)
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Analysis Tools
