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| Nomenclature |
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Symbol:
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Dsg3tm1Stan
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Name:
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desmoglein 3;
targeted mutation 1, John R Stanley
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MGI ID: |
MGI:1857388 |
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Synonyms: |
Dsg3- |
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Gene:
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Dsg3
Location:
Chr18:20510304-20541310 bp, + strand
Genetic Position: Chr18,
11.39 cM
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Dsg3tm1Stan/Dsg3tm1Stan mice are runts and have skin erosions and eye lesions
Show the 6 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:40804
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Replacement of part of the first exon, including the translation initiation site, with a neomycin cassette. Dsg3 RNA and protein were not detected in mice homozygous for this targeted mutation. (J:40804)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:40804
Koch PJ et al.,
"Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris."
J Cell Biol 1997 Jun 2;137(5):1091-102
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All: |
17 reference(s)
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Analysis Tools
