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| Nomenclature |
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Symbol:
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Plgtm1Jld
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Name:
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plasminogen;
targeted mutation 1, Jay L Degen
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MGI ID: |
MGI:1857291 |
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Synonyms: |
Plg-, Plg0 |
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Gene:
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Plg
Location:
Chr17:12378609-12419384 bp, + strand
Genetic Position: Chr17,
8.5 cM
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Gross appearance of aortic arches of Apoetm1Bres/Apoetm1Bres, Plgtm1Jld/Plgtm1Jld and Apoetm1Bres/Apoetm1Bres Plgtm1Jld/Plgtm1Jld mice
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:39419
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A PGK-HPRT minigene replaces proximal promoter sequences and the first two exons of the gene. Northern analysis and enzymatic activity assays were used to demonstrate the lack of a transcript and functional protein, respectively, in homozygous mutant animals. (J:39419)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:39419
Bugge TH et al.,
"Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction."
Genes Dev 1995 Apr 1;9(7):794-807
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All: |
57 reference(s)
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Analysis Tools
