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| Nomenclature |
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Symbol:
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Plautm1Mlg
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Name:
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plasminogen activator, urokinase;
targeted mutation 1, Richard C Mulligan
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MGI ID: |
MGI:1857289 |
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Synonyms: |
u-PA-, uPA-, UPA- |
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Gene:
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Plau
Location:
Chr14:20836662-20843388 bp, + strand
Genetic Position: Chr14,
11.53 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:17427
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The gene was disrupted using neomycin resistance cassette. The vector replaced genomic sequences encompassing all but 23 amino acids of the coding sequence. Targeting was confirmed by the absence of gene specific mRNA and immunoreactivity. (J:17427)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:17427
Carmeliet P et al.,
"Physiological consequences of loss of plasminogen activator gene function in mice."
Nature 1994 Mar 31;368(6470):419-24
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All: |
90 reference(s)
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Analysis Tools
