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| Nomenclature |
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Symbol:
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Plattm1Mlg
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Name:
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plasminogen activator, tissue;
targeted mutation 1, Richard C Mulligan
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MGI ID: |
MGI:1857288 |
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Synonyms: |
Plattm1, t-PA-, tPA- |
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Gene:
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Plat
Location:
Chr8:22757744-22782847 bp, + strand
Genetic Position: Chr8,
11.42 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:17427
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The gene was disrupted using neomycin resistance cassette. The vector replaced genomic sequences encoding most of the kringle-2 domain and part of the proteinase domain, including the catalytically essential histidine residue at position 326. Targeting was confirmed by the absence of gene specific mRNA and immunoreactivity. (J:17427)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:17427
Carmeliet P et al.,
"Physiological consequences of loss of plasminogen activator gene function in mice."
Nature 1994 Mar 31;368(6470):419-24
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All: |
120 reference(s)
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Analysis Tools
