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| Nomenclature |
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Symbol:
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Cybbtm1Din
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Name:
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cytochrome b-245, beta polypeptide;
targeted mutation 1, Mary C Dinauer
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MGI ID: |
MGI:1857284 |
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Synonyms: |
Cybb KO, Cybbtm1, Cybbtm1Din, gp91-, gp91phox, gp91phox-, gp91phox-, Nox-2-, NOX2-, PHOX-, X-CGD |
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Gene:
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Cybb
Location:
ChrX:9435252-9487771 bp, - strand
Genetic Position: ChrX,
4.3 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:22868
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Parent Cell Line:
| CCE/EK.CCE (ES Cell) |
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Strain of Origin:
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129S/SvEv-Gpi1c
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance gene was inserted into exon 3. Western blot analysis on extracts of neutrophil-rich peritoneal exudate cells from hemizygous male mice confirmed that no detectable protein was expressed. (J:22868)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:22868
Pollock JD et al.,
"Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production."
Nat Genet 1995 Feb;9(2):202-9
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All: |
249 reference(s)
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Analysis Tools
