|
|
| Nomenclature |
|
Symbol:
|
Jak3tm1Ljb
|
|
Name:
|
Janus kinase 3;
targeted mutation 1, Leslie J Berg
|
|
MGI ID: |
MGI:1857276 |
|
Synonyms: |
Jak-3-, Jak3- |
|
Gene:
|
Jak3
Location:
Chr8:71676296-71690575 bp, + strand
Genetic Position: Chr8,
34.43 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:29722
|
|
Parent Cell Line:
| J1 (ES Cell) |
|
Strain of Origin:
|
129S4/SvJae
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: A neomycin resistance cassette replaced a 0.6 kb fragment of the gene, which contains sequences encoding subdomains I to IV of the kinase domain. Protein immunoblots of lysates from bone marrow, spleen, and thymus showed no targeted protein. (J:29722)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:29722
Thomis DC et al.,
"Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3."
Science 1995 Nov 3;270(5237):794-7
|
|
All: |
23 reference(s)
|
|
Analysis Tools
