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| Nomenclature |
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Symbol:
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Vldlrtm1Her
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Name:
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very low density lipoprotein receptor;
targeted mutation 1, Joachim Herz
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MGI ID: |
MGI:1857267 |
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Synonyms: |
VLDLR- |
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Gene:
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Vldlr
Location:
Chr19:27216484-27254231 bp, + strand
Genetic Position: Chr19,
21.77 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:28591
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Parent Cell Line:
| JH1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The insertion of a neomycin selection cassette into exon 5 deleted a portion of the coding sequence and disrupted the reading frame. Immunoblot analysis of heart muscle membranes did not detect protein in homozygous mutant animals. (J:28591)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:28591
Frykman PK et al.,
"Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor."
Proc Natl Acad Sci U S A 1995 Aug 29;92(18):8453-7
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All: |
52 reference(s)
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Analysis Tools
