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| Nomenclature |
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Symbol:
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Tnfrsf1btm1Mwm
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Name:
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tumor necrosis factor receptor superfamily, member 1b;
targeted mutation 1, Mark Moore
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MGI ID: |
MGI:1857262 |
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Synonyms: |
p75-, p75TNFR2-, TNF-R2-, TNFR20, Tnfr2tm1Mwm, TNFR II -, TNFRp75- |
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Gene:
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Tnfrsf1b
Location:
Chr4:145213463-145246870 bp, - strand
Genetic Position: Chr4,
78.17 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:21815
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: Exon 2, which codes for the signal peptide region, was disrupted by the insertion of a neomycin cassette. To confirm that the gene was correctly targeted, mice were challenged with lipopolysaccharide (LPS) which results in shedding of the Tnfrsf1b extracellular domian in wild-type mice. No soluble Tnfrsf1b was detected in the serum of homozygous mutant animals. (J:21815)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:21815
Erickson SL et al.,
"Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice."
Nature 1994 Dec 8;372(6506):560-3
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All: |
120 reference(s)
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Analysis Tools
