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| Nomenclature |
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Symbol:
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Tgfb3tm1Doe
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Name:
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transforming growth factor, beta 3;
targeted mutation 1, Thomas Doetschman
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MGI ID: |
MGI:1857259 |
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Synonyms: |
TGF-beta3 null |
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Gene:
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Tgfb3
Location:
Chr12:86056744-86079041 bp, - strand
Genetic Position: Chr12,
40.09 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:29901
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced exon 6, which encodes the active domain of the protein. RT-PCR analysis of RNA derived from whole E11.5 or E15.5 embryos did not detect any transcript produced from this allele in homozygous mice. (J:29901)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:29901
Proetzel G et al.,
"Transforming growth factor-beta 3 is required for secondary palate fusion."
Nat Genet 1995 Dec;11(4):409-14
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All: |
25 reference(s)
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Analysis Tools
