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| Nomenclature |
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Symbol:
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Tgfb1tm1Doe
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Name:
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transforming growth factor, beta 1;
targeted mutation 1, Thomas Doetschman
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MGI ID: |
MGI:1857258 |
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Synonyms: |
Tgfb1-, TGFbeta1 |
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Gene:
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Tgfb1
Location:
Chr7:25687002-25705077 bp, + strand
Genetic Position: Chr7,
13.98 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:2892
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin resistance cassette was inserted into exon 6 of the gene, disrupting the production of a mature peptide. (J:2892)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:2892
Shull MM et al.,
"Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease."
Nature 1992 Oct 22;359(6397):693-9
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All: |
59 reference(s)
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Analysis Tools
