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| Nomenclature |
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Symbol:
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Tcrdtm1Mom
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Name:
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T cell receptor delta chain;
targeted mutation 1, Peter Mombaerts
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MGI ID: |
MGI:1857257 |
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Synonyms: |
C-delta-, delta-, delta0, gammadelta TCR-, TCRdelta-, TCRdelta KO |
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Gene:
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Tcrd
Location:
unknown
Genetic Position: Chr14,
Syntenic
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:3865
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Parent Cell Line:
| Other (see notes) (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A PGK-neo cassette was used to disrupt the constant gene segment (designated C-delta). Flow cytometry showed that cells isolated from the lymphoid or epithelial organs of homozygous mice did not react with an anti-pan Tcrd mAb. Immunoprecipitation showed an absence of expression on the surface of thymocytes isolated from homozygous mutant embryos. (J:3865, J:91942)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
ES cell line = E14 (129P2/OlaHsd) or D3 (129S2/SvPas).
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| References |
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Original: |
J:3865
Itohara S et al.,
"T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes."
Cell 1993 Feb 12;72(3):337-48
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All: |
325 reference(s)
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Analysis Tools
