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| Nomenclature |
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Symbol:
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Rag1tm1Mom
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Name:
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recombination activating gene 1;
targeted mutation 1, Peter Mombaerts
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MGI ID: |
MGI:1857241 |
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Synonyms: |
Rag-, Rag1-, RAG-1-, Rag-1KO, RAG1null, Rag1tm1Mom |
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Gene:
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Rag1
Location:
Chr2:101638282-101649501 bp, - strand
Genetic Position: Chr2,
53.88 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:1934
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Parent Cell Line:
| AB1 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprt+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 1356 bp genomic fragment of the Rag1 gene, encoding the nuclear localization signal and the zinc-finger motif, was replaced by a neomycin cassette. A mutant transcript expressed from this allele was detected by Northern blot in bone marrow derived cell lines from homozygous mice. (J:1934, J:96036)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:1934
Mombaerts P et al.,
"RAG-1-deficient mice have no mature B and T lymphocytes."
Cell 1992 Mar 6;68(5):869-77
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All: |
645 reference(s)
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Analysis Tools
