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| Nomenclature |
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Symbol:
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Ptgs1tm1Unc
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Name:
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prostaglandin-endoperoxide synthase 1;
targeted mutation 1, University of North Carolina
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MGI ID: |
MGI:1857238 |
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Synonyms: |
COX-1-, PGHS-1-, Ptgs1-, Ptgstm1Smi |
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Gene:
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Ptgs1
Location:
Chr2:36230426-36252272 bp, + strand
Genetic Position: Chr2,
24.19 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:29511
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A ~1 kb genomic fragment containing intron 10, and the first 44 bp of exon 11 was replaced with a neomycin selection cassette. Northern blot analysis on colon and kidney RNA demonstrated that a 1.1 kb aberrant transcript was produced from this allele. Western blot analysis on kidney, stomach or colon tissue lysates derived from homozygous mice confirmed that no detectable protein is produced from this allele, and additional western blots on proteins derived from LPS-induced macrophages derived from homozygous mice demonstrated that no encoded protein was present. (J:29511)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ptgs1 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:29511
Langenbach R et al.,
"Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration."
Cell 1995 Nov 3;83(3):483-92
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All: |
88 reference(s)
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Analysis Tools
