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| Nomenclature |
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Symbol:
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Prf1tm1Sdz
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Name:
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perforin 1 (pore forming protein);
targeted mutation 1, Sandoz Pharmaceuticals
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MGI ID: |
MGI:1857235 |
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Synonyms: |
P0, perf-, perforin-, perforin 0, Pfn-, pfp-, pfpKO, Pfptm1Sdz, pko, Prf-, Prf1-, prf1tm1, Prf1tm/Sdz |
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Gene:
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Prf1
Location:
Chr10:61297836-61304263 bp, + strand
Genetic Position: Chr10,
32.18 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:17986
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Parent Cell Line:
| BL/6-III (ES Cell) |
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Strain of Origin:
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C57BL/6J
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin selection cassette was inserted into exon 3. RT-PCR analysis on RNA derived from homozygous mice demonstrated that an abnormal transcript was produced from this allele. However, immunocytochemistry experiments on activated spleen cells derived from homozygous mice confirmed that no detectable protein was made from this allele. (J:17986, J:96542)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: hemophagocytic lymphohistiocytosis in mutants infected with lymphocytic choriomeningitic virus (J:92260)
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| References |
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Original: |
J:17986
Kagi D et al.,
"Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice [see comments]"
Nature 1994 May 5;369(6475):31-7
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All: |
217 reference(s)
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Analysis Tools
