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| Nomenclature |
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Symbol:
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Nos3tm1Unc
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Name:
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nitric oxide synthase 3, endothelial cell;
targeted mutation 1, University of North Carolina
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MGI ID: |
MGI:1857229 |
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Synonyms: |
ecNOS-, eNOS-, eNOSKO, NOS3- |
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Gene:
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Nos3
Location:
Chr5:24364810-24384474 bp, + strand
Genetic Position: Chr5,
11.32 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:36559
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 1.2 kb neomycin cassette replaced 129 bp of exon 12 of the gene. This disrupted the calmodulin binding site of the protein and introduced a premature stop codon into the transcripts. Immunohistochemisty of heart and kidney sections from homozygous mutant mice confirmed that no detectable encoded protein was present. (J:36559)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Aortic Valve Disease in Homozygous mice (J:103340)
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| References |
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Original: |
J:36559
Shesely EG et al.,
"Elevated blood pressures in mice lacking endothelial nitric oxide synthase."
Proc Natl Acad Sci U S A 1996 Nov 12;93(23):13176-81
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All: |
245 reference(s)
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Analysis Tools
