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| Nomenclature |
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Symbol:
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Nos2tm1Lau
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Name:
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nitric oxide synthase 2, inducible;
targeted mutation 1, Victor E Laubach
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MGI ID: |
MGI:1857228 |
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Synonyms: |
iNOS-, iNOS KO, NOS2-, Nos2tm1Lau, NOS2tm/Lau |
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Gene:
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Nos2
Location:
Chr11:78920787-78960254 bp, + strand
Genetic Position: Chr11,
46.74 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:29677
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin cassette replaced exons 12 and 13 of the gene, which encode the calmodulin-binding domain. Northern and Western blots of IFNg/LPS-stimulated peritoneal macrophages showed no detectable Nos2 mRNA or protein, respectively. (J:29677, J:183641)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:29677
Laubach VE et al.,
"Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death."
Proc Natl Acad Sci U S A 1995 Nov 7;92(23):10688-92
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All: |
339 reference(s)
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Analysis Tools
