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| Nomenclature |
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Symbol:
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Myod1tm1Jae
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Name:
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myogenic differentiation 1;
targeted mutation 1, Rudolf Jaenisch
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MGI ID: |
MGI:1857221 |
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Synonyms: |
MyoD (-), MyoD-, MyoDml |
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Gene:
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Myod1
Location:
Chr7:46376474-46379092 bp, + strand
Genetic Position: Chr7,
30.03 cM
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Dmdmdx/? Myod1tm1Jae/Myod1tm1Jae mice develop cardiomyopathy
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:3070
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Replacement of the MyoD promoter, exon 1 and half of intron 1 with a neomycin cassette. (J:3070)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:3070
Rudnicki MA et al.,
"Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development."
Cell 1992 Oct 30;71(3):383-90
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All: |
56 reference(s)
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Analysis Tools
