|
|
| Nomenclature |
|
Symbol:
|
Itgb2tm1Bay
|
|
Name:
|
integrin beta 2;
targeted mutation 1, Baylor College of Medicine
|
|
MGI ID: |
MGI:1857208 |
|
Synonyms: |
CD18-, CD18hypo, CD18low, Itgb2hypo |
|
Gene:
|
Itgb2
Location:
Chr10:77530252-77565708 bp, + strand
Genetic Position: Chr10,
39.72 cM
|
|
Clinical features and histopathology of psoriasiform skin disease in Itgb2tm1Bay/Itgb2tm1Bay mice
Show the 3 image(s) involving this allele.
|
 |
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:13599
|
|
Parent Cell Line:
| AB1 (ES Cell) |
|
Strain of Origin:
|
129S7/SvEvBrd-Hprt+
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: An insertion mutation that duplicates exons 2 and 3 with interruption of one copy of exon 3 with a neomycin cassette. This is not a null mutation but rather a hypomorph expressing very low levels of ITGB2 protein. (J:13599)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
|
Notes |
Homozygous or trans heterozgous mice (Itgb2tm1Bay / Itgb2tm2Bay) on a mixed background that includes the strain PL/J and trans heterozygous mice on a congenic PL/J background display Phenotypic Similarity to Human Syndrome: Psoriasis. However, mice on backgrounds that do not include PL/J do not display psoriasis. (J:32126, J:84126)
|
| References |
|
Original: |
J:13599
Wilson RW et al.,
"Gene targeting yields a CD18-mutant mouse for study of inflammation."
J Immunol 1993 Aug 1;151(3):1571-8
|
|
All: |
40 reference(s)
|
|
Analysis Tools
