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| Nomenclature |
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Symbol:
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Il10tm1Cgn
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Name:
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interleukin 10;
targeted mutation 1, University of Cologne
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MGI ID: |
MGI:1857199 |
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Synonyms: |
Il10-, IL-10-, IL-10KO, IL-10KO, IL-10 KO, Il10tmCgn |
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Gene:
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Il10
Location:
Chr1:131019845-131024974 bp, + strand
Genetic Position: Chr1,
56.89 cM
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Characterization of Il10tm1Cgn/Il10tm1Cgn mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:15222
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 500 bp genomic fragment containing codons 5-55 was replaced with a linker containing a termination codon followed by a neomycin cassette. A termination codon was also introduced into exon 3. No IL10 activity was detectable by ELISA assays in supernatants of in vitro cultures of Con A-stimulated splenic T cells derived from homozygous mice following infection with the nematode N. brasiliensis. (J:15222)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Idiopathic Inflammatory Bowel Disease (J:15222).
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| References |
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Original: |
J:15222
Kuhn R et al.,
"Interleukin-10-deficient mice develop chronic enterocolitis [see comments]"
Cell 1993 Oct 22;75(2):263-74
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All: |
560 reference(s)
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Analysis Tools
