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| Nomenclature |
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Symbol:
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Il6tm1Kopf
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Name:
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interleukin 6;
targeted mutation 1, Manfred Kopf
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MGI ID: |
MGI:1857197 |
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Synonyms: |
Il6-, IL-6-, IL-6 KO, Il6tm1Koe, Il6tm1Kopf |
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Gene:
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Il6
Location:
Chr5:30013161-30019968 bp, + strand
Genetic Position: Chr5,
15.7 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:17360
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin selection cassette was inserted into exon 2. RT-PCR experiments on RNA derived from LPS-stimulated macrophages of homozygous mice demonstrated that no detectable transcript was produced from this allele. ELISA and bioassay experiments confirmed that no functional protein was made in homozygous mice. (J:17360)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:17360
Kopf M et al.,
"Impaired immune and acute-phase responses in interleukin-6-deficient mice."
Nature 1994 Mar 24;368(6469):339-42
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All: |
410 reference(s)
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Analysis Tools
