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| Nomenclature |
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Symbol:
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Il4tm2Nnt
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Name:
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interleukin 4;
targeted mutation 2, Nancy Noben-Trauth
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MGI ID: |
MGI:1857195 |
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Synonyms: |
IL-4- |
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Gene:
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Il4
Location:
Chr11:53602982-53618669 bp, - strand
Genetic Position: Chr11,
31.97 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:36386
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Parent Cell Line:
| BALB/c-I (ES Cell) |
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Strain of Origin:
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BALB/cJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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A neomycin resistance cassette was inserted into exon 3 of the gene. (J:36386)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Susceptibility to Leishmania major in BALB/c mice has been ablated by introduction of a null mutant of the Il4 gene (J:35236), but in that study the introduced mutant came from a strain 129 background, and 129 is resistant to L. major infection. In mice carrying one of Noben-Trauth's null mutants, targeted in BALB/c embryonic stem cells, the loss of Il4 expression did not remove susceptibility to infection (J:31486).
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| References |
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Original: |
J:36386
Noben-Trauth N et al.,
"Efficient targeting of the IL-4 gene in a BALB/c embryonic stem cell line."
Transgenic Res 1996 Nov;5(6):487-91
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All: |
80 reference(s)
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Analysis Tools
