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| Nomenclature |
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Symbol:
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Il2ratm1Dw
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Name:
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interleukin 2 receptor, alpha chain;
targeted mutation 1, Dennis M Willerford
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MGI ID: |
MGI:1857192 |
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Synonyms: |
CD25-, CD25KO, IL-2Ralpha-, IL2Ralpha-, IL-2Ralpha KO |
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Gene:
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Il2ra
Location:
Chr2:11642792-11693191 bp, + strand
Genetic Position: Chr2,
8.91 cM, cytoband A2-A3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:64279
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced a 5.5 kb segment of the gene, containing exons 2 and 3, which encode for the binding site of the protein. (J:64279)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Inflammatory Bowel Disease (J:64279).
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| References |
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Original: |
J:64279
Willerford DM et al.,
"Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment."
Immunity 1995 Oct;3(4):521-30
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All: |
49 reference(s)
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Analysis Tools
