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| Nomenclature |
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Symbol:
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Il2tm1Hor
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Name:
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interleukin 2;
targeted mutation 1, Ivan Horak
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MGI ID: |
MGI:1857191 |
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Synonyms: |
Il2-, IL-2-, IL-2 KO, IL-2null |
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Gene:
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Il2
Location:
Chr3:37120523-37125959 bp, - strand
Genetic Position: Chr3,
18.3 cM, cytoband B-C
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:39989
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: Insertion of a neomycin-resistance gene into the third exon introduced several stop codons in all reading frames. (J:39989)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: Inflammatory Bowel Disease (J:15223).
Phenotypic Similarity to Human Syndrome: Inflammatory Bowel Disease (J:51450) with B2m.
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| References |
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Original: |
J:39989
Schorle H et al.,
"Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting."
Nature 1991 Aug 15;352(6336):621-4
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All: |
159 reference(s)
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Analysis Tools
