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| Nomenclature |
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Symbol:
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Htttm1Mem
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Name:
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huntingtin;
targeted mutation 1, Marcy E MacDonald
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MGI ID: |
MGI:1857180 |
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Synonyms: |
Hdh-, Hdhex4/5, Hdhnull, R1Hdh4/5-1d1 |
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Gene:
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Htt
Location:
Chr5:34761740-34912534 bp, + strand
Genetic Position: Chr5,
17.92 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:27183
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
| |
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A neomycin resistance cassette replaced exons 4 and 5 of the gene. (J:27183)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:27183
Duyao MP et al.,
"Inactivation of the mouse Huntington's disease gene homolog Hdh."
Science 1995 Jul 21;269(5222):407-10
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All: |
11 reference(s)
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Analysis Tools
