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| Nomenclature |
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Symbol:
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Hbbtm1Unc
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Name:
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hemoglobin beta chain complex;
targeted mutation 1, University of North Carolina
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MGI ID: |
MGI:1857179 |
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Synonyms: |
Hbbth2 |
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Gene:
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Hbb
Location:
unknown
Genetic Position: Chr7,
Syntenic
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:4932
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin resistance cassette was inserted into exon 2 of the beta1 gene. No protein for the targeted gene was detected via cellulose electrophoresis of hemoglobin from homozygous mutant mice. (J:4932)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:4932
Shehee WR et al.,
"Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene."
Proc Natl Acad Sci U S A 1993 Apr 15;90(8):3177-81
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All: |
1 reference(s)
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Analysis Tools
