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| Nomenclature |
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Symbol:
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En2tm1Alj
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Name:
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engrailed 2;
targeted mutation 1, Alexandra L Joyner
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MGI ID: |
MGI:1857164 |
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Synonyms: |
En2-, en-2hd |
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Gene:
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En2
Location:
Chr5:28165696-28173612 bp, + strand
Genetic Position: Chr5,
13.94 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:67524
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced 1 kb of sequence containing 300 bp of intron and 700 bp of the homeobox exon. (J:67524)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Mice heterozygous for En1tm1Gld and homozygous for En2tm1Alj display Phenotypic Similarity to Human Syndrome: Parkinson Disease (J:115270)
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| References |
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Original: |
J:67524
Joyner AL et al.,
"Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox."
Science 1991 Mar 8;251(4998):1239-43
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All: |
22 reference(s)
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Analysis Tools
