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| Nomenclature |
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Symbol:
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Klf1tm1Sho
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Name:
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Kruppel-like factor 1 (erythroid);
targeted mutation 1, Stuart Orkin
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MGI ID: |
MGI:1857162 |
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Synonyms: |
EKLF- |
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Gene:
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Klf1
Location:
Chr8:84901928-84905295 bp, + strand
Genetic Position: Chr8,
41.3 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:25651
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced a portion of intron 2 and exon 2, which encodes the zinc-finger DNA-binding domain of the protein. No stable RNA for the targeted gene was detected by RNase protection using RNA from homozygous mutant embryos. (J:25651)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:25651
Perkins AC et al.,
"Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF."
Nature 1995 May 25;375(6529):318-22
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All: |
18 reference(s)
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Analysis Tools
