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| Nomenclature |
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Symbol:
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Gzmbtm1Ley
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Name:
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granzyme B;
targeted mutation 1, Timothy J Ley
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MGI ID: |
MGI:1857156 |
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Synonyms: |
Granzyme B-, GrB KO, GrzB-, gzmB-, Gzmb-, Gzmb-/+PGK-neo |
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Gene:
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Gzmb
Location:
Chr14:56258856-56262260 bp, - strand
Genetic Position: Chr14,
28.19 cM, cytoband D3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:23560
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A PGK-neomycin resistance cassette replaced a 350bp AvrII fragment starting within the 5' untranslated region (22 bp upstream from the initiation codon), extending through exon 1 and part of intron 1. (J:23560)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:23560
Heusel JW et al.,
"Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells."
Cell 1994 Mar 25;76(6):977-87
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All: |
64 reference(s)
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Analysis Tools
