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| Nomenclature |
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Symbol:
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Csf3tm1Ard
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Name:
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colony stimulating factor 3 (granulocyte);
targeted mutation 1, Ashley R Dunn
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MGI ID: |
MGI:1857155 |
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Synonyms: |
G-CSF- |
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Gene:
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Csf3
Location:
Chr11:98701263-98703629 bp, + strand
Genetic Position: Chr11,
62.45 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:20400
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 0.7kb genomic fragment containing exons 1-3 was replaced by a lacZ gene and neomycin resistance cassette. This mutation placed the lacZ gene under the control of the Csf3 promoter elements. An activity assay demonstrated that the functional protein was not detectable in cultured medium derived from organ cultures of various tissues of homozygous mice. (J:20400)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:20400
Lieschke GJ et al.,
"Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization."
Blood 1994 Sep 15;84(6):1737-46
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All: |
20 reference(s)
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Analysis Tools
