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| Nomenclature |
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Symbol:
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Cd8atm1Mak
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Name:
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CD8 antigen, alpha chain;
targeted mutation 1, Tak Mak
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MGI ID: |
MGI:1857149 |
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Synonyms: |
CD8-, CD8alpha-, CD8alpha-, Cd8atm1Mak, CD8KO, CD8 KO, CD8-KO, Lyt-2- |
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Gene:
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Cd8a
Location:
Chr6:71373427-71379171 bp, + strand
Genetic Position: Chr6,
32.14 cM, cytoband C
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:68956
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin resistance gene was inserted into exon 1. Flow cytometry analysis on thymus and lymph node cells derived from homozygous mice confirmed that no detectable encoded protein was expressed on the cell surface. (J:68956, J:82297)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:68956
Fung-Leung WP et al.,
"CD8 is needed for development of cytotoxic T cells but not helper T cells."
Cell 1991 May 3;65(3):443-9
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All: |
207 reference(s)
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Analysis Tools
