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| Nomenclature |
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Symbol:
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Cd40lgtm1Imx
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Name:
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CD40 ligand;
targeted mutation 1, Immunex
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MGI ID: |
MGI:1857145 |
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Synonyms: |
CD154-, CD40L-, CD40LKO, Tnfsf5tm1Imx |
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Gene:
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Cd40lg
Location:
ChrX:57212143-57224042 bp, + strand
Genetic Position: ChrX,
31.21 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:21137
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 3 and 4 were replaced with a neomycin cassette. Homozygous mutant animals fail to express functional protein on the cell surface. (J:21137)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:21137
Renshaw BR et al.,
"Humoral immune responses in CD40 ligand-deficient mice."
J Exp Med 1994 Nov 1;180(5):1889-900
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All: |
122 reference(s)
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Analysis Tools
