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| Nomenclature |
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Symbol:
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Btktm1Wk
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Name:
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Bruton agammaglobulinemia tyrosine kinase;
targeted mutation 1, Wasif Kahn
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MGI ID: |
MGI:1857138 |
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Synonyms: |
Btk-, Btk-kin-/GL, BtkM |
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Gene:
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Btk
Location:
ChrX:134542336-134583570 bp, - strand
Genetic Position: ChrX,
56.18 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:28968
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A genomic fragment containing exons 13 and 14 was replaced with a neomycin resistance cassette. These sequences encode the beginning of the kinase domain. (J:28968)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:28968
Khan WN et al.,
"Defective B cell development and function in Btk-deficient mice."
Immunity 1995 Sep;3(3):283-99
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All: |
66 reference(s)
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Analysis Tools
