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| Nomenclature |
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Symbol:
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Nek8jck
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Name:
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NIMA (never in mitosis gene a)-related expressed kinase 8;
juvenile cystic kidney
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MGI ID: |
MGI:1856919 |
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Synonyms: |
jck, Nek8- |
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Gene:
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Nek8
Location:
Chr11:78166106-78176675 bp, - strand
Genetic Position: Chr11,
46.74 cM, cytoband B5
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Mutation
origin |
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Strain of Origin:
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C57BL/6J Tg 147-9a
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Mutation
description |
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Allele
Type: | |
Spontaneous |
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Mutation: | |
Single point mutation |
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Mutation details: The mutation in jck mice has been identified as a nucleotide substitution (G1348T), resulting in a nonconservative amino acid substitution of valine for glycine at amino acid 488 in the C-terminal domain of the protein. (J:79896)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:11885
Atala A et al.,
"Juvenile cystic kidneys (jck): a new mouse mutation which causes polycystic kidneys."
Kidney Int 1993 May;43(5):1081-5
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All: |
16 reference(s)
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Analysis Tools
