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| Nomenclature |
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Symbol:
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Mregdsu
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Name:
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melanoregulin;
dilute suppressor
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MGI ID: |
MGI:1856847 |
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Synonyms: |
dsu |
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Gene:
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Mreg
Location:
Chr1:72159233-72212307 bp, - strand
Genetic Position: Chr1,
36.39 cM
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Myo5ad/ Myo5ad and Myo5ad/ Myo5ad Mregdsu/ Mregdsu
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Strain of Origin:
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STOCK a Myo5ad cw
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Mutation
description |
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Allele
Type: | |
Spontaneous |
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Mutation: | |
Intragenic deletion |
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Mutation details: Genomic PCR and DNA sequencing analysis showed the mutation is a deletion that spans the region from 11.1-kb upstream of the initiator methionine to intron 2. Northern and RT-PCR analysis demonstrated that no wild-type transcript could be detected in the mutant animals. Western blot analysis of homozygous mutant melanocytes showed that it also is not expressed at the protein level. (J:94728)
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Inheritance: | |
Semidominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:7171
Sweet HO,
"Dilute suppressor, a new suppressor gene in the house mouse."
J Hered 1983 Jul-Aug;74(4):305-6
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All: |
10 reference(s)
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Analysis Tools
